| Common Molecule Notifies Immune System Of Prostate Cancer
In experiments with mice, researchers have found that the body's immune system can use a surprisingly common molecule to recognize prostate tumors. The molecule comes from a protein found in all cells of the body; however, immune cells appear to respond to it only when it is present on the surface of cells within a tumor.Understanding how this protein, known as histone H4, signals the immune system to respond to malignant cells may help researchers refine immunotherapy strategies that harness the body's own immune system to fight tumors. Some types of immunotherapy are already being tested in patients, but many questions remain unanswered. In particular, researchers want to know if tumor cells display molecular signposts that tell the immune system, "I'm a cancer cell, destroy me."Howard Hughes Medical Institute investigator James P.
Immune System Notified Of Prostate Cancer By Common Molecule
In experiments with mice, researchers have found that the body's immune system can use a surprisingly common molecule to recognize prostate tumors. The molecule comes from a protein found in all cells of the body; however, immune cells appear to respond to it only when it is present on the surface of cells within a tumor.
Understanding how this protein, known as histone H4, signals the immune system to respond to malignant cells may help researchers refine immunotherapy strategies that harness the body's own immune system to fight tumors. Some types of immunotherapy are already being tested in patients, but many questions remain unanswered. In particular, researchers want to know if tumor cells display molecular signposts that tell the immune system, "I'm a cancer cell, destroy me."
Howard Hughes Medical Institute investigator James P.
Perils ahead for manager who set the bar too high
My job was to put on the pitch what they wanted to watch. In the end this quest for attacking perfection tied a noose round my neck because I stuck to it throughout, even when the championship was at stake." Now the club crave more of the same, but you have to wonder how easily it will be recaptured. Presumably only by throwing money at the problem. As the world knows, Keegan was no great tactician and often overlooked from his first spell on Tyneside is that he scrapped the reserve team, which was to prove hugely shortsighted. He will not be able to break transfer records, as he did in his first spell. .
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