| Androgen Deprivation Therapy-induced Fractures in Men With ...
Androgen deprivation therapy (ADT), such as orchiectomy or gonadotropin-releasing hormone agonist therapy, is increasingly used for the treatment of localized, high-risk, or biochemical relapse of prostate cancer. Bone mineral density loss is associated with ADT, presenting an increased risk for fractures, and strategies for preventing bone loss include antiresorptive therapy and lifestyle changes, such as smoking cessation and reduced alcohol consumption. Androgen Deprivation Therapy-induced Fractures in Men With Nonmetastatic Prostate Cancer: What Do We Really Know?
Celestia S. Higano, MD
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Dendreon Completes Target Enrollment of 500 Patients in Phase 3 IMPACT ...
SEATTLE, Oct. 23 /PRNewswire-FirstCall/ -- Dendreon Corporation (NASDAQ: DNDN) today announced that the Company has completed enrollment of over 500 patients in the Phase 3 IMPACT (IMmunotherapy for Prostate AdenoCarcinoma Treatment, also known as D9902B) clinical trial of PROVENGE (sipuleucel-T), the Company's investigational active cellular immunotherapy for the treatment of advanced prostate cancer. The IMPACT study is a double-blind, randomized, placebo-controlled Phase 3 trial designed to measure overall survival in men with metastatic hormone-refractory prostate cancer receiving PROVENGE versus placebo. Earlier this year, following a positive recommendation from an outside panel of experts, Dendreon received a complete response letter from the U.S. Food and Drug Administration (FDA) that asked for additional evidence that would support the efficacy of PROVENGE.
Veterinarian treated pets of stars -- and kids
McGee had been battling multiple ailments for the past five years: bone cancer, a stroke and a heart attack. He died at 86. As an old-timer, McGee could ''diagnose a lot of problems that younger doctors needed lots of tests'' to pinpoint, said Brian Sens, co-owner of Pet Parade in Miami, where McGee worked part time until last year. He'd closed Miami Veterinarian Hospital, 3520 NW 36th St., in 1997, after 51 years. He served on the Florida Veterinary Medical Board and was a past president of the South Florida Veterinary Association. ''Some doctors and vet techs have a natural ability to calm the animals, and he was one of them,'' Sens said. ``Even the aggressive ones, he was able to work with them.'' McGee lived the ''laughter is the best medicine'' philosophy: ''a funny guy [who] loved things like Richard Pryor,'' Sens said.
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